Pelizaeus Merzbacher syndrome: brief review of the literature

Abstract

Introduction: Myelin diseases have been described since the 19th century, leucodsitrophiaes are a heterogeneous group of diseases, of progressive course, that can manifest a wide range of symptoms and complications, mostly of genetic aetiology, being Syndrome of Pelizaeuz Merzbacher, of inheritance linked to the X chromosome, the most frequent of these. Objective: provide an up-to-date overview of the epscial demyelinating diseases of the Pelizaeuz Merzbacher syndrome. Material and method: the most relevant articles considered by the authors were selected in PubMed; EBSCO; Thomson Reuters and OvidSP. Results: Merzbacher Pelizaeuz Syndrome presents important clinical heterogeneity and unfortunately at the moment does not have an effective treatment, however new stem cell technologies provide opportunities for its treatment.